NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.

doi:10.1038/ncb3590

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Article

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program.

Nature cell biology - 1 Sept 2017

Hiraike Yuta, Waki Hironori, Yu Jing, Nakamura Masahiro, Miyake Kana, Nagano Gaku, Nakaki Ryo, Suzuki Ken, Kobayashi Hirofumi, Yamamoto Shogo, Sun Wei, Aoyama Tomohisa, Hirota Yusuke, Ohno Haruya, Oki Kenji, Yoneda Masayasu, White Andrew P, Tseng Yu-Hua, Cypess Aaron M, Larsen Therese J, Jespersen Naja Z, Scheele Camilla, Tsutsumi Shuichi, Aburatani Hiroyuki, Yamauchi Toshimasa, Kadowaki Takashi

Abstract excerpt

Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis of brown-fat-specific open chromatin regions. NFIA and the master transcriptional regulator of adipogenesis, PPARγ, co-localize at the brown-fat-specific...

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PMID: 28812581
DOI: 10.1038/ncb3590
PMCID: PMC5885759

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NFIA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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