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The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas.

mBio - 15 Aug 2017

Kurthkoti Krishna, Amin Hamel, Marakalala Mohlopheni J, Ghanny Saleena, Subbian Selvakumar, Sakatos Alexandra, Livny Jonathan, Fortune Sarah M, Berney Michael, Rodriguez G Marcela

Abstract excerpt

This study was conducted to investigate the role of iron deprivation in the persistence of Mycobacterium tuberculosis We present evidence of iron restriction in human necrotic granulomas and demonstrate that under iron starvation M. tuberculosis persists, refractive to antibiotics and capable of restarting replication when iron is made available. Transcriptomics and metabolomic analyses indicated that the...

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Identifiers

PMID: 28811344
DOI: 10.1128/mBio.01092-17
PMCID: PMC5559634

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