Elbasvir plus grazoprevir in patients with hepatitis C virus infection and stage 4-5 chronic kidney disease: clinical, virological, and health-related quality-of-life outcomes from a phase 3, multicentre, randomised, double-blind, placebo-controlled trial.

doi:10.1016/S2468-1253(17)30116-4

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Elbasvir plus grazoprevir in patients with hepatitis C virus infection and stage 4-5 chronic kidney disease: clinical, virological, and health-related quality-of-life outcomes from a phase 3, multicentre, randomised, double-blind, placebo-controlled trial.

The lancet. Gastroenterology & hepatology - 1 Aug 2017

Bruchfeld Annette, Roth David, Martin Paul, Nelson David R, Pol Stanislas, Londoño Maria-Carlota, Monsour Howard, Silva Marcelo, Hwang Peggy, Arduino Jean-Marie, Robertson Michael, Nguyen Bach-Yen, Wahl Janice, Barr Eliav, Greaves Wayne

Abstract excerpt

BACKGROUND: In the C-SURFER study, therapy with the all-oral elbasvir plus grazoprevir regimen for 12 weeks in patients with chronic hepatitis C virus (HCV) infection and stage 4-5 chronic kidney disease resulted in a high rate of virological cure compared with placebo. Here, we report sustained virological response (SVR), safety data, health-related quality-of-life (HRQOL), and virological resistance analyses in...

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PMID: 28576451
DOI: 10.1016/S2468-1253(17)30116-4

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