Article
NanoString-based breast cancer risk prediction for women with sclerosing adenosis.
Breast cancer research and treatment - 1 Nov 2017
Winham Stacey J, Mehner Christine, Heinzen Ethan P, Broderick Brendan T, Stallings-Mann Melody, Nassar Aziza, Vierkant Robert A, Hoskin Tanya L, Frank Ryan D, Wang Chen, Denison Lori A, Vachon Celine M, Frost Marlene H, Hartmann Lynn C, Aubrey Thompson E, Sherman Mark E, Visscher Daniel W, Degnim Amy C, Radisky Derek C
Abstract excerpt
PURPOSE: Sclerosing adenosis (SA), found in ¼ of benign breast disease (BBD) biopsies, is a histological feature characterized by lobulocentric proliferation of acini and stromal fibrosis and confers a two-fold increase in breast cancer risk compared to women in the general population. We evaluated a NanoString-based gene expression assay to model breast cancer risk using RNA derived from formalin-fixed,...
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