Patterns of coding variation in the complete exomes of three Neandertals.

doi:10.1073/pnas.1405138111

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Article

Patterns of coding variation in the complete exomes of three Neandertals.

Proceedings of the National Academy of Sciences of the United States of America - 6 May 2014

Castellano Sergi, Parra Genís, Sánchez-Quinto Federico A, Racimo Fernando, Kuhlwilm Martin, Kircher Martin, Sawyer Susanna, Fu Qiaomei, Heinze Anja, Nickel Birgit, Dabney Jesse, Siebauer Michael, White Louise, Burbano Hernán A, Renaud Gabriel, Stenzel Udo, Lalueza-Fox Carles, de la Rasilla Marco, Rosas Antonio, Rudan Pavao, Brajković Dejana, Kucan Željko, Gušic Ivan, Shunkov Michael V, Derevianko Anatoli P, Viola Bence, Meyer Matthias, Kelso Janet, Andrés Aida M, Pääbo Svante

Abstract excerpt

We present the DNA sequence of 17,367 protein-coding genes in two Neandertals from Spain and Croatia and analyze them together with the genome sequence recently determined from a Neandertal from southern Siberia. Comparisons with present-day humans from Africa, Europe, and Asia reveal that genetic diversity among Neandertals was remarkably low, and that they carried a higher proportion of amino acid-changing...

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PMID: 24753607
DOI: 10.1073/pnas.1405138111
PMCID: PMC4020111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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