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Impact of Paracoccin Gene Silencing on Paracoccidioides brasiliensis Virulence

19 Jul 2017

Abstract excerpt

ABSTRACT Among the endemic deep mycoses in Latin America, paracoccidioidomycosis (PCM), caused by thermodimorphic fungi of the Paracoccidioides genus, is a major cause of morbidity. Disease development and its manifestations are associated with both host and fungal factors. Concerning the latter, several recent studies have employed the methodology of gene modulation in P. brasiliensis using antisense RNA (AsRNA)...

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PMID: 28720727
DOI: 10.1128/mbio.00537-17

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