Article
A pair of DICER1-positive monozygotic twins: One with pleuropulmonary blastoma, another with acute transient hepatitis.
Pediatric blood & cancer - 1 Dec 2017
Li Sihui, Cai Siyu, Wang Xisi, Zhang Dawei, Fu Libing, Zeng Qi, Peng Xiaoxia, Ma Xiaoli
Abstract excerpt
Pleuropulmonary blastoma (PPB) is the most common primary malignant neoplasm of the lung in children that is associated with a germline mutation in DICER1. In this report, we share an interesting case of a pair of monozygotic twins: one of them developed PPB when she was 4-year old, while the other developed acute transient hepatitis when she was 5-year old. Next-Gen sequencing for DICER1 mutations of their...
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