Article
Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.
Journal of child psychology and psychiatry, and allied disciplines - 1 Dec 2017
Van Assche Evelien, Moons Tim, Cinar Ozan, Viechtbauer Wolfgang, Oldehinkel Albertine J, Van Leeuwen Karla, Verschueren Karine, Colpin Hilde, Lambrechts Diether, Van den Noortgate Wim, Goossens Luc, Claes Stephan, van Winkel Ruud
Abstract excerpt
BACKGROUND: Most gene-environment interaction studies (G × E) have focused on single candidate genes. This approach is criticized for its expectations of large effect sizes and occurrence of spurious results. We describe an approach that accounts for the polygenic nature of most psychiatric phenotypes and reduces the risk of false-positive findings. We apply this method focusing on the role of perceived parental...
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