Article
The use of cell culture platforms to identify novel markers of bone and dentin resorption.
Orthodontics & craniofacial research - 1 Jun 2017
Rody W J, Krokhin O, Spicer V, Chamberlain C A, Chamberlain M, McHugh K P, Wallet S M, Emory A K, Crull J D, Holliday L S
Abstract excerpt
OBJECTIVES: 1) To test the hypothesis that there would be proteomic differences in the composition of exosomes isolated from osteoclasts and odontoclasts and 2) to determine the clinical usefulness of these in vitro biomarker candidates. MATERIALS AND METHODS: Mouse bone marrow-derived precursors were cultured on either dentin or bone slices and allowed to mature and begin resorption. Exosomes were isolated from...
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