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Article

Genomic rearrangements in sporadic lymphangioleiomyomatosis: an evolving genetic story.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2017

Murphy Stephen J, Terra Simone B, Harris Faye R, Nasir Aqsa, Voss Jesse S, Smadbeck James B, Johnson Sarah H, Serla Vishnu, Ryu Jay H, Yi Eunhee S, Kipp Benjamin R, Vasmatzis George, Carmona Eva M

Abstract excerpt

Sporadic lymphangioleiomyomatosis is a progressive pulmonary cystic disease resulting from the infiltration of smooth muscle-like lymphangioleiomyomatosis cells into the lung. The migratory/metastasizing properties of the lymphangioleiomyomatosis cell together with the presence of somatic mutations, primarily in the tuberous sclerosis complex gene (TSC2), lead many to consider this a low-grade malignancy. As...

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Source

Identifiers

PMID: 28643793
DOI: 10.1038/modpathol.2017.52

Genes

TSC2
TSC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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