Article
Is there an association between IFN-γ +874A/T polymorphism and periodontitis susceptibility?: A meta-analysis.
Medicine - 1 Jun 2017
Shi Quan, Cai Chuan, Xu Juan, Liu Jinglong, Liu Hongchen, Huo Na
Abstract excerpt
BACKGROUND: Interferon-γ (IFN-γ) is a key proinflammatory cytokine which plays a critical role in the pathogenesis and progression of periodontitis. The single nucleotide polymorphism of +874A/T in human IFN-γ gene can influence the secretion of IFN-γ and affect periodontitis susceptibility. However, the findings of published studies are inconsistent. Therefore, the goal of this meta-analysis is to investigate...
Topics
- Genetic Predisposition to Disease
- Humans
- Interferon-gamma
- Periodontitis
- Polymorphism, Single Nucleotide