Article
Low 17β-estradiol Levels Are Better Inducers of Regulatory Conditioned T Cells In-Vitro.
Iranian journal of immunology : IJI - 1 Jun 2017
Fatemi Ramina, Mirzadegan Ebrahim, Vahedian Zohreh, Zarnani Amir Hassan, Jeddi-Tehrani Mahmood, Idali Farah
Abstract excerpt
BACKGROUND: 17β-estradiol (E2) has been known to modulate immune response. Recent studies indicate that E2 at pregnancy level plays a role in regulating T cell response. OBJECTIVE: To investigate the optimum dose of E2 (from 10-9 to 10-7 M) in mediating the generation of regulatory T cells (Tregs), using naive human CD4+ T cells from healthy women. METHODS: Naive peripheral T cells were purified and conditioned...
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