Article
Differentiated demographic histories and local adaptations between Sherpas and Tibetans.
Genome biology - 15 Jun 2017
Zhang Chao, Lu Yan, Feng Qidi, Wang Xiaoji, Lou Haiyi, Liu Jiaojiao, Ning Zhilin, Yuan Kai, Wang Yuchen, Zhou Ying, Deng Lian, Liu Lijun, Yang Yajun, Li Shilin, Ma Lifeng, Zhang Zhiying, Jin Li, Su Bing, Kang Longli, Xu Shuhua
Abstract excerpt
BACKGROUND: The genetic relationships reported by recent studies between Sherpas and Tibetans are controversial. To gain insights into the population history and the genetic basis of high-altitude adaptation of the two groups, we analyzed genome-wide data in 111 Sherpas (Tibet and Nepal) and 177 Tibetans (Tibet and Qinghai), together with available data from present-day human populations. RESULTS: Sherpas and...
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