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Article

Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Aug 2017

Marchiori Elena, Pelizzo Maria Rosa, Herten Monika, Townsend Danyelle M, Rubello Domenico, Boschin Isabella Merante

Abstract excerpt

OBJECTIVE: Sporadic carcinoma of the parathyroid glands is a rare malignant neoplasia. The GCM2 gene encodes a transcription factor that is crucial to embryonic parathyroid development. The Y282D variant of GCM2 exhibits increased transcriptional activity, and the presence of this variant is significantly associated with a higher prevalence of primitive hyperparathyroidism. The present study investigated the...

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Source

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Identifiers

PMID: 28609842
DOI: 10.1016/j.biopha.2017.05.028
PMCID: PMC6361162

Genes

GCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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