Article
Genetic variation in potential Giardia vaccine candidates cyst wall protein 2 and α1-giardin.
Parasitology research - 1 Aug 2017
Radunovic Matej, Klotz Christian, Saghaug Christina Skår, Brattbakk Hans-Richard, Aebischer Toni, Langeland Nina, Hanevik Kurt
Abstract excerpt
Giardia is a prevalent intestinal parasitic infection. The trophozoite structural protein a1-giardin (a1-g) and the cyst protein cyst wall protein 2 (CWP2) have shown promise as Giardia vaccine antigen candidates in murine models. The present study assesses the genetic diversity of a1-g and CWP2 between and within assemblages A and B in human clinical isolates. a1-g and CWP2 sequences were acquired from 15...
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