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Article

Comparative analysis of genes frequently regulated by drugs based on connectivity map transcriptome data.

PloS one - 1 Jan 2017

Liu Xinhua, Zeng Pan, Cui Qinghua, Zhou Yuan

Abstract excerpt

Gene expression is perturbated by drugs to different extent. Analyzing genes whose expression is frequently regulated by drugs would be useful for the screening of candidate therapeutic targets and genes implicated in side effect. Here, we obtained the differential expression number (DEN) for genes profiled in Affymetrix microarrays from the Connectivity Map project, and conducted systemic comparative...

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Identifiers

PMID: 28575118
DOI: 10.1371/journal.pone.0179037
PMCID: PMC5456389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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