Article
Efflux Transporter of Siderophore Staphyloferrin A in Staphylococcus aureus Contributes to Bacterial Fitness in Abscesses and Epithelial Cells.
Infection and immunity - 1 Aug 2017
Nakaminami Hidemasa, Chen Chunhui, Truong-Bolduc Que Chi, Kim Eu Suk, Wang Yin, Hooper David C
Abstract excerpt
The siderophores staphyloferrin A (SA) and staphyloferrin B (SB) of Staphylococcus aureus are essential for iron acquisition in the iron-restricted environment of the host, such as in subcutaneous abscesses. SA and SB are secreted by SfaA and SbnD transporters, respectively. To assess the further function of SfaA and SbnD in S. aureus fitness, we tested its effect on murine abscess models and intracellular...
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