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Article

The ATP-Dependent Protease ClpP Inhibits Biofilm Formation by Regulating Agr and Cell Wall Hydrolase Sle1 in Staphylococcus aureus.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Liu Qian, Wang Xing, Qin Juanxiu, Cheng Sen, Yeo Won-Sik, He Lei, Ma Xiaowei, Liu Xiaoyun, Li Min, Bae Taeok

Abstract excerpt

Biofilm causes hospital-associated infections on indwelling medical devices. In Staphylococcus aureus, Biofilm formation is controlled by intricately coordinated network of regulating systems, of which the ATP-dependent protease ClpP shows an inhibitory effect. Here, we demonstrate that the inhibitory effect of ClpP on biofilm formation is through Agr and the cell wall hydrolase Sle1. Biofilm formed by clpP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28555174
DOI: 10.3389/fcimb.2017.00181
PMCID: PMC5430930

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