Article
BRCA-associated Cancers: Role of Imaging in Screening, Diagnosis, and Management.
Radiographics : a review publication of the Radiological Society of North America, Inc - 1 Jan 2000
Lee Michelle V, Katabathina Venkata S, Bowerson Michyla L, Mityul Marina I, Shetty Anup S, Elsayes Khaled M, Balachandran Aparna, Bhosale Priya R, McCullough Ann E, Menias Christine O
Abstract excerpt
Harmful mutations of the BRCA tumor suppressor genes result in a greater lifetime risk for malignancy-breast and ovarian cancers in particular. An increased risk for male breast, fallopian tube, primary peritoneal, pancreatic, prostate, and colon cancers also has been reported. The BRCA gene is inherited in an autosomal dominant pattern and tends to be highly penetrant; thus, there is an increased incidence of...
Topics
- Diagnostic Imaging
- Genes, BRCA1
- Genes, BRCA2
- Genetic Predisposition to Disease
- Humans
- Neoplasms
- Risk Factors