Article
Interaction of molecular alterations with immune response in melanoma.
Cancer - 1 Jun 2017
Szczepaniak Sloane Robert A, Gopalakrishnan Vancheswaran, Reddy Sangeetha M, Zhang Xue, Reuben Alexandre, Wargo Jennifer A
Abstract excerpt
Major advances have been made in melanoma treatment with the use of molecularly targeted therapies and immunotherapies, and numerous regimens are now approved by the US Food and Drug Administration for patients with stage IV disease. However, therapeutic resistance remains an issue to both classes of agents, and reliable biomarkers of therapeutic response and resistance are lacking. Mechanistic insights are being...
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