Article
Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp.
Oncogene - 28 Sept 2017
Zhang Y, Hu Y, Wang J-L, Yao H, Wang H, Liang L, Li C, Shi H, Chen Y, Fang J-Y, Xu J
Abstract excerpt
Mutation of the TP53 gene represents a prevalent genetic alteration in human cancers, and a subset of p53 mutants may form amyloid-like aggregates that contribute to the gain of oncogenic functions (GOFs) and chemoresistance. Here we identify the pathways that may mediate the aggregation-associated GOF by using combined proteomic analysis and genome-wide recruitment profiling. Mass spectrometry revealed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.