Article
Extracolonic cancer risk in Dutch patients with APC (adenomatous polyposis coli)-associated polyposis.
Journal of medical genetics - 1 Jan 2018
Ghorbanoghli Zeinab, Bastiaansen Barbara Aj, Langers Alexandra Mj, Nagengast Fokko M, Poley Jan-Werner, Hardwick James Ch, Koornstra Jan J, Sanduleanu Silvia, de Vos Tot Nederveen Cappel Wouter H, Witteman Ben Jm, Morreau H, Dekker Evelien, Vasen Hans Fa
Abstract excerpt
BACKGROUND: Screening of patients with familial adenomatous polyposis (FAP) have led to a substantial reduction in mortality due to colorectal cancer (CRC). Recent guidelines suggest that surveillance of non-intestinal malignancies should also be considered in those patients. However, the value of these surveillance programmes is unknown. The aims of this study were (1) to assess the occurrence of extracolonic...
Topics
- Adenomatous Polyposis Coli
- Adult
- Cause of Death
- Colorectal Neoplasms
- Female
- Genes, APC
- Genetic Predisposition to Disease
- Humans
- Male
- Mutation
- Netherlands
- Risk Factors