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Article

Analysis of global DNA methylation changes in primary human fibroblasts in the early phase following X-ray irradiation

10 May 2017

Abstract excerpt

Epigenetic alterations may contribute to the generation of cancer cells in a multi-step process of tumorigenesis following irradiation of normal body cells. Primary human fibroblasts with intact cell cycle checkpoints were used as a model to test whether X-ray irradiation with 2 and 4 Gray induces direct epigenetic effects (within the first cell cycle) in the exposed cells. ELISA-based fluorometric assays were...

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PMID: 28489894
DOI: 10.1371/journal.pone.0177442

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