Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells

24 Apr 2017

Abstract excerpt

Autophagy is a crucial and physiological process for cell survival from yeast to mammals, including protozoan parasites. Toxoplasma gondii, an intracellular parasite, typically exploits autophagic machinery of host cell; however host cell upregulates autophagy to combat the infection. Herein we tested the efficacy of Rottlerin, a natural polyphenol with autophagic promoting properties, against Toxoplasma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cytomegalovirus and herpesvirus research
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28455500
DOI: 10.1038/s41598-017-01525-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rottlerin-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cellsPMID 28455500Read ↗

Modulation of autophagy as a therapeutic strategy for Toxoplasma gondii infectionSemantic proximity Read ↗

How Toxoplasma and malaria parasites defy first, then exploit host autophagic and endocytic pathways for growthSemantic proximity Read ↗

Different Drugs, Same End: Ultrastructural Hallmarks of Autophagy in Pathogenic ProtozoaSemantic proximity Read ↗

Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell deathSemantic proximity Read ↗

Toxoplasma gondii inhibits the expression of autophagy-related genes through AKT-dependent inactivation of the transcription factor FOXO3aSemantic proximity Read ↗

Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites.Semantic proximity Read ↗

<i>Toxoplasma</i> TgATG2 works with TgATG9 and TgProp1 to drive autophagic flux for parasite extracellular survival and persistenceSemantic proximity Read ↗

Review of Experimental Compounds Demonstrating Anti-Toxoplasma ActivitySemantic proximity Read ↗

Toxoplasma TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite.Semantic proximity Read ↗

Pleiotropic effect due to targeted depletion of secretory rhoptry protein ROP2 inToxoplasma gondiiSemantic proximity Read ↗

Myrislignan Exhibits Activities Against Toxoplasma gondii RH Strain by Triggering Mitochondrial DysfunctionSemantic proximity Read ↗

Autophagy is a cell death mechanism in Toxoplasma gondiiSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.