Article
Whole-exome sequencing points to considerable genetic heterogeneity of cerebral palsy.
Molecular psychiatry - 1 Feb 2015
McMichael G, Bainbridge M N, Haan E, Corbett M, Gardner A, Thompson S, van Bon B W M, van Eyk C L, Broadbent J, Reynolds C, O'Callaghan M E, Nguyen L S, Adelson D L, Russo R, Jhangiani S, Doddapaneni H, Muzny D M, Gibbs R A, Gecz J, MacLennan A H
Abstract excerpt
Cerebral palsy (CP) is a common, clinically heterogeneous group of disorders affecting movement and posture. Its prevalence has changed little in 50 years and the causes remain largely unknown. The genetic contribution to CP causation has been predicted to be ~2%. We performed whole-exome sequencing of 183 cases with CP including both parents (98 cases) or one parent (67 cases) and 18 singleton cases (no parental...
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