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Article

Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer

11 Apr 2017

Abstract excerpt

Androgen-ablation therapies, which are the standard treatment for metastatic prostate cancer, invariably lead to acquired resistance. Hence, a systematic identification of additional drivers may provide useful insights into the development of effective therapies. Numerous microRNAs that are critical for metastasis are dysregulated in metastatic prostate cancer, but the underlying molecular mechanism is poorly...

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PMID: 28397780
DOI: 10.1038/ncomms14917

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