Article
A combination of mecillinam and amoxicillin/clavulanate can restore susceptibility of high-level TEM-1-producing Escherichia coli to mecillinam.
The Journal of antimicrobial chemotherapy - 1 Jul 2017
Birgy André, Delecourt Marine, Geslain Guillaume, Desselas Emilie, Caseris Marion, Magnan Mélanie, Mariani-Kurkdjian Patricia, Bidet Philippe, Bonacorsi Stéphane
Abstract excerpt
Objectives: Mecillinam is recommended in France as a first-line treatment for lower urinary tract infections, due to the large increase in resistance of Escherichia coli to other oral treatments, such as co-trimoxazole or fluoroquinolones, its limited impact on faecal microbiota and its stability in the presence of numerous β-lactamases. However, we recently identified several mecillinam-resistant E. coli...
Topics
- Amdinocillin
- Amoxicillin-Potassium Clavulanate Combination
- Anti-Bacterial Agents
- Drug Therapy, Combination
- Escherichia coli
- Escherichia coli Infections
- France
- Genome, Bacterial
- Humans
- Microbial Sensitivity Tests
- Penicillinase
- Polymorphism, Single Nucleotide