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Article

Azole-resistant Aspergillus fumigatus harboring TR34/L98H, TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia.

Scientific reports - 30 Mar 2017

Alvarez-Moreno Carlos, Lavergne Rose-Anne, Hagen Ferry, Morio Florent, Meis Jacques F, Le Pape Patrice

Abstract excerpt

Resistance to triazoles in Aspergillus fumigatus has been reported in azole-naive patients in Europe, Asia, Australia and North America. This resistance has been linked to fungicide-driven mutations in the cyp51A gene and its promoter region. We investigated the presence of environmental azole-resistant A. fumigatus strains related to the use of azole fungicides in Colombia. Soil samples were collected from...

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PMID: 28358115
DOI: 10.1038/srep45631
PMCID: PMC5372364

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