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Article

Cytoreductive conditioning intensity predicts clonal diversity in ADA-SCID retroviral gene therapy patients

28 Mar 2017

Abstract excerpt

cell dose. These data, in combination with results of other ADA-SCID gene therapy trials, suggest that disease background may be a crucial factor in leukemogenic potential of retroviral gene therapy and underscore the importance of cytoreductive conditioning in this type of gene therapy approach.

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Identifiers

PMID: 28351939
DOI: 10.1182/blood-2016-12-756734

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