Article
Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder.
Scientific reports - 28 Mar 2017
Coretti Lorena, Cristiano Claudia, Florio Ermanno, Scala Giovanni, Lama Adriano, Keller Simona, Cuomo Mariella, Russo Roberto, Pero Raffaela, Paciello Orlando, Mattace Raso Giuseppina, Meli Rosaria, Cocozza Sergio, Calignano Antonio, Chiariotti Lorenzo, Lembo Francesca
Abstract excerpt
Alterations of microbiota-gut-brain axis have been invoked in the pathogenesis of autism spectrum disorders (ASD). Mouse models could represent an excellent tool to understand how gut dysbiosis and related alterations may contribute to autistic phenotype. In this study we paralleled gut microbiota (GM) profiles, behavioral characteristics, intestinal integrity and immunological features of colon tissues in BTBR...
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