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Article

Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160

16 Dec 2016

Abstract excerpt

Laminin-111 protein complex links the extracellular matrix to integrin α7β1 in sarcolemma, thus replacing in dystrophic muscles links normally insured by the dystrophin complex. Laminin-111 injection in mdx mouse stabilized sarcolemma, restored serum creatine kinase to wild-type levels, and protected muscles from exercised-induced damages. These results suggested that increased laminin-111 is a potential therapy...

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PMID: 28325301
DOI: 10.1016/j.omtn.2016.11.004

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