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Article

Novel mutations in CRYGC are associated with congenital cataracts in Chinese families.

Scientific reports - 15 Mar 2017

Zhong Zilin, Wu Zehua, Han Liyun, Chen Jianjun

Abstract excerpt

Congenital cataract (CC), responsible for about one-third of blindness in infants, is a major cause of vision loss in children worldwide. 10-25% of CC cases are attributed to genetic causes and CC is a clinically and genetically highly heterogeneous lens disorder in children. Autosomal dominant (AD) inheritance is the most commonly pattern. 195 unrelated non-syndromic ADCC families in this study are recruited...

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Asian People
Cataract
China
gamma-Crystallins
Genetic Association Studies
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

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Identifiers

PMID: 28298635
DOI: 10.1038/s41598-017-00318-1
PMCID: PMC5428270

Genes

CRYGC

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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