Article
CD4+ memory T cells retain surface expression of CD31 independently of thymic function in patients with lymphoproliferative disorders following autologous hematopoietic stem-cell transplantation.
International journal of hematology - 1 Jul 2017
Batorov Egor V, Tikhonova Marina A, Kryuchkova Irina V, Sergeevicheva Vera V, Sizikova Svetlana A, Ushakova Galina Y, Batorova Dariya S, Gilevich Andrey V, Ostanin Alexander A, Shevela Ekaterina Y, Chernykh Elena R
Abstract excerpt
High-dose chemotherapy with autologous hematopoietic stem-cell transplantation (AHSCT) causes severe and long-lasting immunodeficiency in patients with lymphoproliferative disorders. The thymus begins to restore the T-cell repertoire approximately from the sixth month post-transplant. We assessed the dynamics of post-transplant recovery of CD4+CD45RA+CD31+ T cells, "recent thymic emigrants" (RTEs), and a poorly...
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