Article
Correlative analysis of plasma SN-38 levels and DPD activity with outcomes of FOLFIRI regimen for metastatic colorectal cancer with UGT1A1 *28 and *6 wild type and its implication for individualized chemotherapy.
Cancer biology & therapy - 4 Mar 2017
Cai Xun, Tian Chuan, Wang Liwei, Zhuang Rongyuan, Zhang Xiaowei, Guo Yuanbiao, Lu Hongmin, Wang Hui, Li Xiaoyu, Gao Junwei, Li Qi, Wang Chungang
Abstract excerpt
It remains uncertain whether there is an correlation between clinical pharmacokinetic parameters and outcomes for metastatic colorectal cancer especially with UGT1A1 *28 and *6 wild type (*1/*1-*1/*1) for serious events associated with Irinotecan are largely excluded. This study retrospectively analyzed the relationship between Irinotecan metabolite levels and outcomes of UGT1A1 *1/*1-*1/*1 genotype arrangement....
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