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Article

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.

PLoS genetics - 1 Mar 2017

Shadle Sean C, Zhong Jun Wen, Campbell Amy E, Conerly Melissa L, Jagannathan Sujatha, Wong Chao-Jen, Morello Timothy D, van der Maarel Silvère M, Tapscott Stephen J

Abstract excerpt

Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of DUX4 in skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated with stem cell biology and its mis-expression in FSHD cells results in apoptosis. To identify genes and pathways necessary for DUX4-mediated apoptosis, we performed an siRNA screen in an RD rhabdomyosarcoma cell line with an inducible DUX4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscular Dystrophy, Facioscapulohumeral

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Share to Proto-Oncogene Proteins c-myc

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Source

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Identifiers

PMID: 28273136
DOI: 10.1371/journal.pgen.1006658
PMCID: PMC5362247

Genes

DUX4
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.PMID 28273136Read ↗

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