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Article

Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis.

PloS one - 1 Jan 2017

Nielson Jessica L, Cooper Shelly R, Yue John K, Sorani Marco D, Inoue Tomoo, Yuh Esther L, Mukherjee Pratik, Petrossian Tanya C, Paquette Jesse, Lum Pek Y, Carlsson Gunnar E, Vassar Mary J, Lingsma Hester F, Gordon Wayne A, Valadka Alex B, Okonkwo David O, Manley Geoffrey T, Ferguson Adam R

Abstract excerpt

BACKGROUND: Traumatic brain injury (TBI) is a complex disorder that is traditionally stratified based on clinical signs and symptoms. Recent imaging and molecular biomarker innovations provide unprecedented opportunities for improved TBI precision medicine, incorporating patho-anatomical and molecular mechanisms. Complete integration of these diverse data for TBI diagnosis and patient stratification remains an...

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Source

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Identifiers

PMID: 28257413
DOI: 10.1371/journal.pone.0169490
PMCID: PMC5336356

Genes

COMT
DRD2
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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