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House spider genome uncovers evolutionary shifts in the diversity and expression of black widow venom proteins associated with extreme toxicity.

BMC genomics - 16 Feb 2017

Gendreau Kerry L, Haney Robert A, Schwager Evelyn E, Wierschin Torsten, Stanke Mario, Richards Stephen, Garb Jessica E

Abstract excerpt

BACKGROUND: Black widow spiders are infamous for their neurotoxic venom, which can cause extreme and long-lasting pain. This unusual venom is dominated by latrotoxins and latrodectins, two protein families virtually unknown outside of the black widow genus Latrodectus, that are difficult to study given the paucity of spider genomes. Using tissue-, sex- and stage-specific expression data, we analyzed the recently...

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PMID: 28209133
DOI: 10.1186/s12864-017-3551-7
PMCID: PMC5314461

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