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Cytotoxic Fusicoccane-Type Diterpenoids from Streptomyces violascens Isolated from Ailuropoda melanoleuca Feces

16 Feb 2017

Abstract excerpt

Six new fusicoccane-type diterpenoids ( 2 – 7 ) were isolated from the fermentation broth of Streptomyces violascens, which was isolated from Ailuropoda melanoleuca (giant panda) feces. The structures of these new compounds were elucidated by a detailed spectroscopic data and X-ray crystallographic analysis. Compounds 5 – 7 demonstrated cytotoxicity against five human cancer cell lines, with IC 50 values ranging...

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PMID: 28206772
DOI: 10.1021/acs.jnatprod.6b00676

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