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Article

Clinical and molecular aspects of distal renal tubular acidosis in children.

Pediatric nephrology (Berlin, Germany) - 1 Jun 2017

Besouw Martine T P, Bienias Marc, Walsh Patrick, Kleta Robert, Van't Hoff William G, Ashton Emma, Jenkins Lucy, Bockenhauer Detlef

Abstract excerpt

BACKGROUND: Distal renal tubular acidosis (dRTA) is characterized by hyperchloraemic metabolic acidosis, hypokalaemia, hypercalciuria and nephrocalcinosis. It is due to reduced urinary acidification by the α-intercalated cells in the collecting duct and can be caused by mutations in genes that encode subunits of the vacuolar H+-ATPase (ATP6V1B1, ATP6V0A4) or the anion exchanger 1 (SLC4A1). Treatment with alkali...

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Share to Acidosis, Renal Tubular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anion Exchange Protein 1, Erythrocyte

Share to Glomerular Filtration Rate

Share to Kidney Medulla

Share to Kidney Tubules, Collecting

Share to Vacuolar Proton-Translocating ATPases

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Identifiers

PMID: 28188436
DOI: 10.1007/s00467-016-3573-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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