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Article

Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease

1 Feb 2017

Abstract excerpt

The mechanism underlying selective motor neuron (MN) death remains an essential question in the MN disease field. The MN disease spinal muscular atrophy (SMA) is attributable to reduced levels of the ubiquitous protein SMN. Here, we report that SMN levels are widely variable in MNs within a single genetic background and that this heterogeneity is seen not only in SMA MNs but also in MNs derived from controls and...

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Identifiers

PMID: 28178525
DOI: 10.1016/j.celrep.2017.01.035

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