Article
Clustering of 770,000 genomes reveals post-colonial population structure of North America.
Nature communications - 7 Feb 2017
Han Eunjung, Carbonetto Peter, Curtis Ross E, Wang Yong, Granka Julie M, Byrnes Jake, Noto Keith, Kermany Amir R, Myres Natalie M, Barber Mathew J, Rand Kristin A, Song Shiya, Roman Theodore, Battat Erin, Elyashiv Eyal, Guturu Harendra, Hong Eurie L, Chahine Kenneth G, Ball Catherine A
Abstract excerpt
Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within...
Topics
- Cluster Analysis
- Demography
- Emigrants and Immigrants
- Gene Flow
- Genetics, Population
- Genotyping Techniques
- Haplotypes
- Humans
- Polymorphism, Single Nucleotide