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Article

ANRIL: A Regulator of VEGF in Diabetic Retinopathy

25 Jan 2017

Abstract excerpt

Purpose: Long noncoding RNAs (lncRNAs) previously thought to be "dark matter" of the genome, play key roles in various biological processes. The lncRNA ANRIL is located at a genetic susceptibility locus for coronary artery diseases and type 2 diabetes. We examined the role of ANRIL in diabetic retinopathy, through study of its regulation of VEGF both in vitro and in vivo. Methods: Human retinal endothelial cells...

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PMID: 28122089
DOI: 10.1167/iovs.16-20569

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