Article
Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer.
Scientific reports - 25 Jan 2017
Li Xiong, Huang Kecheng, Zhang Qinghua, Zhou Jin, Sun Haiying, Tang Fangxu, Zhou Hang, Hu Ting, Wang Shaoshuai, Jia Yao, Yang Ru, Chen Yile, Cheng Xiaodong, Lv Weiguo, Wu Li, Xing Hui, Wang Lin, Zhou Shasha, Yao Yuan, Wang Xiaoli, Suolang Quzhen, Shen Jian, Xi Ling, Hu Junbo, Wang Hui, Chen Gang, Gao Qinglei, Xie Xing, Wang Shixuan, Li Shuang, Ma Ding
Abstract excerpt
To identify genomic markers associated with the response to neoadjuvant chemotherapy (NACT) in patients with cervical cancer, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. A total of 596 patients with stage IA2-IIIB cervical cancer were enrolled in this study. One single nucleotide polymorphism (SNP) (rs6812281, per allele OR = 2.37, P = 9.0 × 10-9) located at...
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