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Article

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer.

Nature reviews. Cancer - 1 Feb 2017

Dienstmann Rodrigo, Vermeulen Louis, Guinney Justin, Kopetz Scott, Tejpar Sabine, Tabernero Josep

Abstract excerpt

Critical driver genomic events in colorectal cancer have been shown to affect the response to targeted agents that were initially developed under the 'one gene, one drug' paradigm of precision medicine. Our current knowledge of the complexity of the cancer genome, clonal evolution patterns under treatment pressure and pharmacodynamic effects of target inhibition support the transition from a one gene, one drug...

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PMID: 28050011
DOI: 10.1038/nrc.2016.126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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