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Article

Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight

3 Jan 2017

Abstract excerpt

BACKGROUND: Placental Plasmodium falciparum malaria can trigger intervillositis, a local inflammatory response more strongly associated with low birthweight than placental malaria infection alone. Fetal growth (and therefore birthweight) is dependent on placental amino acid transport, which is impaired in placental malaria-associated intervillositis. Here, we tested the hypothesis that mechanistic target of...

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PMID: 28049467
DOI: 10.1186/s12916-016-0759-3

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