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Promising link of HLA-G polymorphism, tobacco consumption and risk of Head and Neck Squamous Cell Carcinoma (HNSCC) in North Indian population.

Human immunology - 1 Feb 2017

Agnihotri Vertica, Gupta Abhishek, Kumar Rahul, Upadhyay Ashish Datt, Dwivedi Sadanand, Kumar Lalit, Dey Sharmistha

Abstract excerpt

Human leukocyte antigen (HLA-G) is a potent immune-tolerant molecule and has a critical role in various pathological conditions of cancer. The aim of the study was to analyze the association of HLA-G polymorphism as a risk factor in Head and Neck Squamous Cell Carcinoma (HNSCC). The HLA-G polymorphism at 3'UTR 14bp INDEL (rs371194629) and +3142G/C (rs1063320) were studied in 383 HNSCC patients and 383 ethnically...

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PMID: 28040535
DOI: 10.1016/j.humimm.2016.12.007

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