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Article

Human papillomavirus status and the relative biological effectiveness of proton radiotherapy in head and neck cancer cells

30 Dec 2016

Abstract excerpt

BACKGROUND: Human papillomavirus (HPV)-positive oropharyngeal carcinomas response better to X-ray therapy (XRT) than HPV-negative disease. Whether HPV status influences the sensitivity of head and neck cancer cells to proton therapy or the relative biological effectiveness (RBE) of protons versus XRT is unknown. METHODS: Clonogenic survival was used to calculate the RBE; immunocytochemical analysis and neutral...

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PMID: 28039958
DOI: 10.1002/hed.24673

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