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ATG16L1 governs placental infection risk and preterm birth in mice and women

21 Dec 2016

Abstract excerpt

The placenta is a barrier against maternal-fetal transmission of pathogens. Placental infections can cause several adverse pregnancy outcomes, including preterm birth (PTB). Yet, we have limited knowledge regarding the mechanisms the placenta uses to control infections. Here, we show that autophagy, a cellular recycling pathway important for host defense against pathogens, and the autophagy gene Atg16L1 play a...

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PMID: 28018968
DOI: 10.1172/jci.insight.86654

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