Article
A homozygous PIGN missense mutation in Soft-Coated Wheaten Terriers with a canine paroxysmal dyskinesia.
Neurogenetics - 1 Jan 2017
Kolicheski Ana L, Johnson Gary S, Mhlanga-Mutangadura Tendai, Taylor Jeremy F, Schnabel Robert D, Kinoshita Taroh, Murakami Yoshiko, O'Brien Dennis P
Abstract excerpt
Hereditary paroxysmal dyskinesias (PxD) are a heterogeneous group of movement disorders classified by frequency, duration, and triggers of the episodes. A young-adult onset canine PxD has segregated as an autosomal recessive trait in Soft-Coated Wheaten Terriers. The medical records and videos of episodes from 25 affected dogs were reviewed. The episodes of hyperkinesia and dystonia lasted from several minutes to...
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