Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.

doi:10.1136/gutjnl-2016-312456

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Article

Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.

Gut - 1 Feb 2018

Henström Maria, Diekmann Lena, Bonfiglio Ferdinando, Hadizadeh Fatemeh, Kuech Eva-Maria, von Köckritz-Blickwede Maren, Thingholm Louise B, Zheng Tenghao, Assadi Ghazaleh, Dierks Claudia, Heine Martin, Philipp Ute, Distl Ottmar, Money Mary E, Belheouane Meriem, Heinsen Femke-Anouska, Rafter Joseph, Nardone Gerardo, Cuomo Rosario, Usai-Satta Paolo, Galeazzi Francesca, Neri Matteo, Walter Susanna, Simrén Magnus, Karling Pontus, Ohlsson Bodil, Schmidt Peter T, Lindberg Greger, Dlugosz Aldona, Agreus Lars, Andreasson Anna, Mayer Emeran, Baines John F, Engstrand Lars, Portincasa Piero, Bellini Massimo, Stanghellini Vincenzo, Barbara Giovanni, Chang Lin, Camilleri Michael, Franke Andre, Naim Hassan Y, D'Amato Mauro

Abstract excerpt

OBJECTIVE: IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in...

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PMID: 27872184
DOI: 10.1136/gutjnl-2016-312456
PMCID: PMC5563477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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